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RNA structure is intimately related to function, yet methods to identify base-paired RNA strands in a transcriptome-wide manner in cells have remained elusive. One recent paper in Cell and two in Molecular Cell describe related methods to identify RNA sequences that interact in living cells, setting the stage for break-throughs in our understanding of RNA structure and function. Just like proteins, RNA molecules adopt 3D structures that are important for their processing and function.
In fact, nearly all textbooks depict messenger RNAs as linear, non-structured, single-stranded molecules. Not only do most RNAs likely have specific 3D structures, but these structures are almost certainly important for the functions of these RNAs.
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Service discovery and matchmaking in a distributed environment has been an active research issue since at least the mid s. Previous work on matchmaking has typically presented the problem and service descriptions as free or structured marked-up text, so that keyword searches, tree-matching or simple constraint solving are sufficient to identify matches.
We discuss the problem of matchmaking for mathematical services, where the semantics play a critical role in determining the applicability or otherwise of a service and for which we use OpenMath descriptions of pre and post-conditions. We describe a matchmaking architecture supporting the use of match plug-ins and describe four kinds of plug-in that we have developed to date. Unable to display preview. Download preview PDF.
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Sharing knowledge and best practices across different levels of an agricultural system promotes health and resilience. The art, however, is not in connecting different people, but in finding ways to facilitate discussions so that voices can be heard and understood outside of individual comfort zones. A Hunger, Nutrition and Climate Justice Dialogue in Dublin last week answered this challenge by aiming to improve food security through cross system dialogues.
The conference brought farmers, policy makers, civil servants, scientists and select business leaders together to share knowledge and to highlight examples of how science and policy makers are successfully working with local populations – especially farmers. The goal was to use dialogue to improve linkages between the issues of hunger, nutrition and climate justice at all levels of the food system.
It recognized the need to better connect to each other, and by extension to better connect the related issues of hunger, nutrition and climate justice across all levels of policy making. In particular, the Learning Circle element of the conference was an important forum for connections and knowledge exchange. Learning Circles featured case study presentations showcasing best practice collaboration between science and local people; and facilitated discussions regarding questions that the case studies spurred.
The Learning Circles generated many ideas and feedback. Others stressed that continuous research is essential to ensuring varietals and soils that are adapted to changing climate conditions. Some held that the private sector should be more involved in hunger, nutrition and climate justice dialogues. Still others stressed the role of women as critical smallholder production agents, and the need for interventions to take gender differences into account. These calls for increasing female farming productivity were countermanded by warnings that any gains in productivity must be measured against what resources might take away from households, particularly children.
These examples represent only a small proportion of the ideas and perspectives captured by the Learning Circles.
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support semantic-based service matchmaking and avoid privacy leakages to untrusted parties. The approach uses situation-aware access control (SA-AC).
Matchmaking is the existing automated process in League of Legends that matches a player to and against other players in games. The system estimates how good a player is based on whom the player beats and to whom the player loses. It knows pre-made teams are an advantage, so it gives pre-made teams tougher opponents than if each player had queued alone or other premades of a similar total skill level Riot Games Inc.
The basic concept is that the system over time understands how strong of a player you are, and attempts to place you in games with people of the same strength. As much as possible, the game tries to create matches that are a coin flip between players who are about the same skill. The Matchmaking System works along with a modified version of the Elo system. From there, the game is played. If a player wins, the player gain points.
On the contrary, if the player loses, he loses points. If the win was “unexpected” i. There are some problems with this, but it generally works out, especially if people use pre-mades a little bit. The System do a few little things to nudge the Elo rating in the right direction when you start out so that people get where they need to get faster. Additionally, newer players gain and lose points more rapidly so that they are able to play in their skill level faster.
Over time, this means that good players end up high rated because they do better than the system expects, until the system is guessing correctly how often they will win.
And then we define behavior equivalence notion based on our formal model and detail the semantic web service matchmaking algorithm based on that notion.
The first major change is that players must register a unique phone number to their account in order to queue for Ranked matches. Players using multiple accounts create a negative matchmaking experience at all skill brackets, so our goal is to add just enough friction to this process that the number of players doing this will be noticeably reduced. Having more players using their primary accounts will have a positive effect on both Ranked and Unranked Matchmaking.
There will be a two-week grace period from today during which players have time to register a number, but starting on May 4th, accounts without a registered number will no longer be eligible for Ranked play. If a phone number is removed from an account after registration, a new number can be added, but there will be a three-month waiting period before the removed number can be registered on a new account.
This is to prevent using the same number on multiple accounts. Online services that provide phone numbers are not allowed. With the return of the Solo Queue, solo players who enter Ranked Matchmaking can now choose to be matched only with other solo players.
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